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Off-label prescribing accounts for roughly 20% of all prescriptions written in the United States

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Insulin resistance is the bodys adaptation to excessive sugar, refined carbohydrates, frequent eating, and fructose consumption

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it freely crosses the cell membrane and inhibits UCP2-mediated proton leakage in mitochondria, increases the mitochondrial membrane potential, increases ATP levels, and closes K (ATP) channels without affecting other mitochondrial functions (Zhang et al., 2006)