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These observations reinforce the need for well-designed randomised controlled trials (RCTs) to validate the findings and expand the evidence base

The tamper-evident seal must be intact and storage conditions must have been maintained

doi: 10.1007/s12035-018-1352-x 149 GombartAFPierreAMagginiS

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The Phase 2 trial showed that participants at 8mg achieved an average of 22.8% body weight reduction at 48 weeks