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538 Amyotrophic lateral sclerosis (ALS) ALS is a neurological disorder that causes progressive degeneration of the motor neurons in the brainstem, spinal cord and cerebral cortex

When the intracellular concentration of calcium rises this transport process is less favorable since the calcium gradient is reduced

Increases in the solar zenith angle reflect an increase in the path sunlight travels through the atmosphere, where the amount of UVR reaching the Earths surface is reduced through scattering and absorption

Interestingly, systemic inflammation has a somewhat opposite effect on microglia-BBB interactions, as initially microglia respond to systemic inflammation by maintaining BBB integrity through direct interactions with endothelial cells

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