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The muscle-growth compounds work in one of two ways
GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the GIP/GLP-1 dual agonist tirzepatide sit at different points on the price map, and the trial programs behind them, STEP (semaglutide, NEJM 2021) and SURMOUNT (tirzepatide, NEJM 2022), describe the compounds rather than any pricing tier
Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig