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Playing a pivotal role in shielding cells from oxidative stress , the potent antioxidant glutathione holds significance

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The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated proteins, is up-regulated by various stressors

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Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability