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It has never been FDA-approved as a drug for any indication, and the absence of a completed phase III trial program means rare, long-term adverse events (including any cancer signal) may not yet be fully characterized in the way they would be for an approved compound

This metabolic shift is characterized by upregulation of rate-limiting glycolytic enzymes such as pyruvate kinase M2 isoform (PKM2) and hexokinase (HK), leading to elevated production of glycolytic end-products, including pyruvate and lactate (Li et al., 2020)

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PTH targets remain uncertain off dialysis

Still, people with a personal or family history of thyroid cancer are advised not to take Ozempic

Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes. Diabetes Spectrum, vol