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If you suspect an adverse reaction to any medicine or supplement, you can report it through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

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But it is not strictly necessary

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Eosin (Sigma) was used to treat the sections for 10 s

The 500 Dalton rule (molecular weight below 500 Da correlates with percutaneous absorption) is a necessary but not sufficient condition, not a guarantee