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Most patients choose a day that positions the peak side effect window away from important professional or social commitments

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By comparing the metabolic features of the Pit-1 ^K216E mouse model with other established GHD models, it becomes evident that the metabolic changes observed, such as decreased adiposity, align with those reported in different models of GHD, supporting the attribution of these changes specifically to GHD Moreover, the responsiveness of the Pit-1 ^K216E mouse to GH treatment further validates its utility as a translational tool for understanding metabolic dysregulation in GHD and assessing therapeutic interventions

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Some researchers prefer it for its closer approximation to natural GHRH signaling

There was a significant increase in body weight in the HFD group compared to that in the normal diet group