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While GWAS studies have identified SNPs in gene loci that play roles in classical hypertension mechanisms (such as vasoconstriction, sodium reabsorption, and sympathetic nervous system activity), the identified gene loci also relate to inflammation and immunity

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Conclusions The concept of the leaky gut, although used to explain the pathogenesis of many common diseases, should be rethought in terms of the available data that support the many means by which luminal substances cross the gut mucosal barrier