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Its two-compound format makes it a popular option for studying how complementary peptide signals behave within controlled experimental systems

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Diabetes Metab Syndr Obes Targets Ther 14:3375 Kolluru GK, Bir SC, Kevil CG (2012) Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing

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For instance, CART knockout (KO) mice exhibited lower alcohol preference than wild-type mice 28 , moreover low alcohol-preferring DBA/2J mice show decreased CART mRNA and peptide expression in the EWcp compared to alcohol-preferring C57BL/6J mice 17