Recent developments Biochemical function -ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and branched chain -keto acid dehydrogenase (BCKDC) are found in the mitochondria and serve to oxidize their respective carboxylated substrates
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Zeevalk et al., 2007)
The compound was never approved as a pharmaceutical treatment for obesity because the Phase 2 clinical trial results, while showing safety and modest efficacy, did not meet the threshold for drug registration
J., Alsweiler, J., & Crowther, C
Ondansetron blocks 5-HT3 receptors both: Peripherally on vagal nerve terminals in the gastrointestinal tract
