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The efficacy and safety of tirzepatide, with a special focus on cardiovascular safety, were investigated in the 52-week SURPASS-4 trial testing tirzepatide versus insulin glargine in adults with T2D and a high cardiovascular risk under inadequate glycemic control at baseline on one to three oral glucose-lowering medications (metformin, sulfonylurea, SGLT-2 inhibitor) (54, 74)

human relevance remains uncertain, and these medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

This new knowledge paves the way for future SLD treatments and holds the potential to significantly enhance the quality of life for many patients worldwide

[PubMed] [Google Scholar] 28.Drucker DJ

Initial studies were done on patients with early, untreated PD

The goal is sustainable weight loss that can be maintained long term rather than dramatic short-term changes