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In the early 21st century, when no disease-modifying treatments for AD were available, diagnostic biomarkers with mechanistic specificity, such as CSF A 142 /tau ratios or amyloid PET imaging, began to serve a dual role as selection biomarkers in clinical trials
To do that, you need to have plenty of antioxidants in your system
Li JH, Zhou A, Lee CD, Shah SN, Ji JH, Senthilkumar V, Padilla ET, Ball AB, Feng Q, Bustillos CG, Riggan L, Greige A, Divakaruni AS, Annese F, Cooley Coleman JA, Skinner SA, Cowan CW, OSullivan TE (2024) MEF2C regulates NK cell effector functions through control of lipid metabolism
The ERO1-PDI axis is thought to be the main pathway for disulfide bond formation in ER (Wang et al., 2014)