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Glucose-induced cAMP elevation in -cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

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The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control

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Improvement in glycaemic parameters using SGLT-2 inhibitor and GLP-1 agonist in combination in an adolescent with diabetes mellitus and Prader-Willi syndrome: a case report