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It plays an important role in energy production by helping transport fatty acids into cells, where they are used as fuel

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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Numbness and tingling in the hands and feet, depression, confusion, or poor memory can also occur

10.1038/srep28621 62 KlafkeJ

BMJ 2003;327:55760