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On the other hand, metformin-treated mice displayed a slight decrease in body weight, fat mass, and circulating glucose, insulin, and leptin levels, which was associated with a modest reduction of HOMA-IR index and a drop in daily food intake (Fig

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Ariyoshi, T., et al

The frequency and severity of gastrointestinal effects represent a significant clinical consideration

Rebound or retention: a meta-analysis of weight regain after the discontinuation of glucagon-like peptide-1 (GLP-1) receptor agonists and other anti-obesity drugs

For people with type 2 diabetes who are also taking insulin or sulfonylureas, there is an increased risk of hypoglycaemia (low blood sugar)