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This ratio is one of the most reliable biomarkers of cellular redox status, measurable by HPLC or enzymatic assay (Forman et al., Mol Aspects Med 2009)

This means it plays a part in preventing iron-deficiency anemia, a common cause of fatigue

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Hydroxocobalamin is known to support the normal reduction of three important compounds: Nitric Oxide (NO) Hydrogen sulfide (H2S) Cyanide It does this by binding to these compounds and then eliminating them from the body