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Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72
(See PRECAUTIONS, Use in the Elderly and PRECAUTIONS, Impaired Hepatic Function.) Elderly In a pharmacokinetic study in elderly individuals (65yrs old), mean (n=10) steady-state cyclobenzaprine AUC values were approximately 1.7 fold (171.0 ng.hr/mL, range 96.1-255.3) higher than those seen in a group of eighteen younger adults (101.4 ng.hr/mL, range 36.1-182.9) from another study
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