Extracellular HSPs can prime antigen-presenting cells, promote cytokine production (e.g., TNF-, IL-6), and contribute to the generation of autoantibodies (124132)
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Moreover, histopathology revealed a Ki-67 proliferation index of 50%, far exceeding the poor-prognosis threshold of 20%, and scattered positivity for H3K27me3
This is consistent with findings from the SUSTAIN-6 and PIONEER trials, which reported reductions in major adverse cardiovascular events (MACE) with semaglutide use
Aronson JK, Ferner RE
Is that what's happening there