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As a consequence, although clinical application of PAC may be considered as safe, in the case of severely depleted GSH levels PAC should be administered with caution, especially in subjects with severe GSH depletion who, again, are those at higher risk of developing severe COVID-19 disease

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doi: 10.3390/ph16070977

Thereby, this pitfall (i.e., the more carriers, the less own peptide activity) is commonly not considered (Saghazadeh et al., 2018

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