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Intravenous injection of ADSC-EVs has been shown to reduce scar size, suppress fibroblast differentiation into myofibroblasts, and increase the ratio of collagen III to collagen I, as well as the ratio of transforming growth factor-3 (TGF-3) to TGF-1, in a mouse incisional wound model [151]

5): First-line medications Anticonvulsants Pregabalin: Demonstrates significant pain reduction and improves sleep and quality of life in several randomized controlled trials (RCTs)

Sinha et al., 2018

The pivotal role of TGF-/Smad pathway in fibrosis pathogenesis and treatment

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When a study protocol requires consistent GH secretion across multiple subjects or time points, the 80-fold difference in bioavailability between injectable and oral formats isn't a variable