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[11] In a randomized controlled trial (RCT) comparing liraglutide, glargine, glimepiride, and sitagliptin (all added to metformin) with a follow-up of five years, glargine and liraglutide were modestly more effective in achieving and maintaining target HbA1c, [20] with no difference in outcomes of microvascular and cardiovascular disease

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The list used to be longer, but two medicationssibutramine (Meridia) and lorcaserin (Belviq)were recently withdrawn due to elevated risks of cardiovascular events and cancer, respectively