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Further research has revealed that, with the assistance of the coactivator PGC-1, FOXO1 regulates glycogenolysis and gluconeogenesis by modulating the expression of G6PC and PCK1
Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40
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Case studies highlight a strong link between low ferritin levels and iron deficiency
doi:10.1001/jamaoncol.2025.2681 Gruber J, Soares dos Santos B, Maro M, et al
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