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Semaglutide Black Box Warning Due to the potential risk for thyroid cancer, semaglutide diabetes and weight loss medications like Rybelsus, Wegovy, and Ozempic carry boxed warnings from the Food and Drug Administration (FDA)

These drugs contain the active ingredient semaglutide

However, full effect may not develop for four to eight weeks as the medication reaches steady-state concentration and the brains appetite circuits fully adapt

However, semaglutide and tirzepatide will likely remain appropriate first line options for patients with less severe obesity or those who prefer established medications with longer safety track records

The study, Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial, was authored by Mette Kruse Klausen, Signe Keller Justesen, Julie Niemann Pedersen, Line Rasmussen, Andreas Jensen, Mathias Ebbesen Jensen, et al.

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