Trulicity (dulaglutide), has held a steady and growing share of the market in GLP-1s for T2D ( Figure 3 )
The Journal of physiology, 532(Pt 2), 283
It binds to melanocortin receptors in the brain, particularly MC4, and triggers dopamine release in the brain pathways tied to sexual motivation and arousal
Suitable for custom formulations at small or large scale
NICE guidance (NG145) recommends checking TSH levels approximately 68 weeks after any significant weight change or dose adjustment of levothyroxine, then annually once stable
Additionally, case studies have shown that while GLP-1 medications can lead to weight loss, 40-60% of this loss might come from lean mass, which necessitates careful management to prevent muscle loss and maintain strength