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In the LEADER (liraglutide) and SUSTAIN-6 (semaglutide) trials [2, 3], the GLP-1RAs rapidly and greatly decreased HbA 1c levels compared to placebo, which may have partly contributed to the increased incidence of diabetic retinopathy complications observed in SUSTAIN-6 (HR: 1.76 [95% CI 1.11, 2.78])

doi: 10.3389/fimmu.2021.666223

How is this combination reconstituted for research

Niacin (Vitamin B3) Mechanism: VLDL synthesis LDL & TG HDL breakdown HDL Effects: HDL (most effective) LDL TG Side Effects: Flushing & pruritus (prevent with aspirin) Hyperglycemia Hyperuricemia (gout) 4

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