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Without adequate nitric oxide, blood vessels become stiffer, resistance increases, and the heart has to work harder to push blood through the system

We thank Mathieu Blanchette for the helpful comments on the paper

Potential drug interactions have not been systematically studied

Although Hanes breakthrough performance could have been due to an assortment of other factors (such as improved training), he did speed up his marathon time by nearly 6%an improvement most experienced marathoners would die for

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