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Soon after this, Bell's team isolated and sequenced the full human glucagon gene which they deposited into a database and published in 1983 in the prestigious journal Nature (Bell, Sangez-Pescador, Laybourn, Najarian)

Another study examined exendin-4 effect on visceral hypersensitivity in colon-sensitized rats [53]

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doi: 10.1016/j.foodqual.2012.04.007

"A young man escalated his dose of retatrutide, he experienced secretory diarrhoea, which was very severe, and he was admitted to hospital requiring a lot of intravenous fluid rehydration," Dr Holt said

Most digestive side effects tend to appear in the first few weeks of treatment, particularly while the dose is being gradually increased