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Aging Cell 22 , e13764 (2023)

Quality assessment A 5-dimensional evaluation of the included studies was conducted using the Cochrane Risk of Bias Assessment Tool (RoB v

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9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution