A post-hoc subgroup analysis of that trial suggested benefit of prasinezumab in subjects with faster progression [209] and a comparison of MDS-UPDRS progression during the 4-year open-label extension phase with historical controls showed divergent trajectories in favour of prasinezumab from year 2 of treatment onwards [210]
This finding was suspected to arise from different genetic backgrounds of study population, degree of sun exposure, and/or different measurement scales [4]
Further controlled biochemical research is required to definitively solve the underlying biological mechanism
Some patients may be able to use FSA or HSA funds for eligible expenses, depending on their plan terms and benefits administrator
Participants clinical data will be anonymised, following an approved internal process, before data are shared to external third parties
Furthermore, a crossover study of intranasal vitamin B12 versus vitamin B12 injections is needed