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The following changes may indicate that the product has degraded and should not be used: Cloudiness or haziness in the solution, which may suggest protein aggregation or contamination Visible particles or floaters suspended within the liquid Discolouration any shift towards brown, orange, or notably deeper yellow tones Crystalline deposits along the walls of the vial or cartridge, which may indicate freezing has occurred Leaking, cracked, or damaged packaging or devices, which compromise sterility It is worth noting that some changes in stability may not be visible to the naked eye, yet the product's potency may still have been compromised by improper storage

Some individuals, particularly those with significant pre-existing congestion, experience extended purging phases of ten to twelve weeks

Safety limits still apply

After 52 weeks, sitagliptin and glipizide had similar mean reductions from baseline in A1C in the intent-to-treat analysis (Table 9)

The SUSTAIN-7 trial compared the GLP-1 RAs Ozempic and Trulicity against each other in individuals that had type 2 diabetes over a 40-week period