Several possible reasons for the lack of efficacy of antioxidants in clinical trials include (i) insufficient antioxidant levels in the target organ, especially in the nervous system, because an integrated bloodbrain barrier (BBB) is a major obstacle to delivering desired substances, including antioxidants, into the CNS
Leiter LA, Bain SC, Hramiak I, Jodar E, Madsbad S, Gondolf T, et al
Limitations of the Evidence The honesty matters
doi: 10.1186/s13223-020-00494-2 [PubMed] 33444815 Casimir-Brown RS, Kennard L, Kayode OS, Siew LQC, Makris M, Tsilochristou O, Chytiroglou E, Nakonechna A, Rutkowski K, Mirakian R, Wagner A
This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis
Despite greater increases in the serum ARG levels and ARG/ADMA ratio, FMD did not improve after CIT supplementation alone