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A meta-analysis of 16 studies showed that subclinical hypothyroidism generally did not increase the risk of most cardiac problems apart from mortality from ischaemic heart disease

Alghamdi SM, Alsulayyim AS, Alasmari AM, Philip KEJ, Buttery SC, Banya WAS, et al

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Injectable hydrogels and advanced biomaterials offer another dimension of control, providing a localized depot for the sustained release of therapeutics

The dose is usually started low and gradually increased over time to minimize side effects and allow the body to adjust