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A total of 1437 patients were randomized

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High concentrations of BCAAs, in turn, exacerbate mitochondrial dysfunction, forming a vicious cycle

For example, CAN often presents with resting tachycardia and orthostatic hypotension, so nonpharmacologic strategies (such as adequate salt intake and physical activities and avoidance of medicine-related hypotension) and pharmacologic strategies (such as midodrine and droxidopa) should be considered to minimize postural symptoms rather than to restore normotension