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Additionally, the R152H mutation in GPX4 is involved in the development of Sedaghatian-type spinal metaphyseal dysplasia, a rare and fatal disease in newborn babies

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It has been reported that matrix metalloprotease (MMP) enzymes are responsible for the proteolytic degradation of ECM, and they play a role in invasion and metastasis due to the high expression of these MMPs in various tumor tissues (Kleiner and Stetler-Stevenson 1999)

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