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In the United States, approximately 42% of adults have obesity [2], and obesity-related costs are estimated at $173 billion annually [3]

doi:10.1089/thy.2023.0506 Lisco G, De Tullio A, Giagulli VA, et al

To mechanistically link these metabolic alterations with gene expression dynamics, we constructed a trans-omic network model integrating differentially expressed genes (pink nodes) and metabolites (blue squares) through known biochemical associations and literature-curated interactions (Fig

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