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23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

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Por eso sus efectos son perifricos: sobre oxidacin de grasa, metabolismo energtico muscular y recuperacin, pero no sobre cognicin