Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis
Glutathione pathways NAC, glycine, selenium, zinc, vitamin C or vitamin E may be considered according to antioxidant demand and tolerance
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A crucial role is played by endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) that act on O 2 and H 2 O 2 , respectively, as well as glutathione peroxidase (Gpx) that uses GSH as co-substrate (Fu and Chung 2018)
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Well review potential interactions, assess synergistic opportunities, and design an integrated protocol that maximizes cognitive enhancement while maintaining safety