We believe that significant efforts should be put into investigating in greater detail the pathways shared by eryptosis and erythronecroptosis, like caspase-8, ROS signaling, Fas/FasL signaling, to collect more evidence on the interplay between these erythrocyte-specific RCDs
Pattern of familial aggregation of vitiligo
Approach Maximum extension Duration Up to 16 weeks Off Period 4+ weeks Notes Reported anecdotally
The oxidative damage mediated by ROS resulting in the defect in control of apoptosis or programmed cell death and delayed clearance of apoptotic cells may prolong interaction between ROS and apoptotic cell macromolecules generating neoepitopes that subsequently broad spectrum of autoantibody formation leading to the tissue damage in SLE [6,7]
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