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3eg), not only supporting the notion that MB07811 is a bona fide liver-targeted TR-selective agonist, but also substantiate our hypothesis that hepatic TR-mediated TH signaling is responsible for the GLP-1-mediated insulinotropic and glucose-lowering effects of T3

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[DOI] [PubMed] [Google Scholar] 27.Arajo J.R., Martel F., Borges N., Keating E

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1 Comprehensive analyses of GLP-1 biology describe receptor expression, ligand binding, and cAMP-dependent intracellular signaling, 2 while broader incretin pharmacology situates the GLP-1 receptor alongside related nutrient-sensing pathways