When these receptors are activated, they initiate intracellular signalling pathways that lead to the release of stored GLP-1 from secretory granules within the L-cells
GLP-1s, while highly effective, are therefore only one piece of a multidisciplinary health care puzzle
Headaches Headaches may occur, especially during the first week
10.1038/nrendo.2012.140 67 MeurotC.MartinC.SudreL.BretonJ.BougaultC.RattenbachR.et al (2022)
It is produced by specialised cells in the small intestine known as L-cells, and plays a central role in regulating blood sugar levels, appetite, and digestion (1,2)
That puts oral semaglutide in a competitive position with injectable semaglutide and narrows the gap with tirzepatide significantly