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Overall, GLP-1 RAs appear to be more efficacious than DPP4 inhibitors in people with type 2 diabetes in terms of improving glycaemic control and reducing body weight (Gilbert and Pratley, 2020)

Reduced basal metabolic rate can cause weight regain

Because retatrutide is investigational, rare or long-term adverse effects may become clearer only after larger studies and longer follow-up

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Rapid weight loss can contribute to muscle loss, whereas a slower reduction in body fat may help preserve lean muscle mass

At the drug level, Mounjaro accounts for 35.2% of total revenue, while Zepbound accounts for 20.8%