The gut-cardiovascular connection: New era for cardiovascular therapy [J]
Dosing strategy for oral BPC-157 takes into account that the peptide needs contact with the damaged mucosal tissue
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In contrast, noncanonical TGF- signaling engages alternative effectors-including -catenin, Mitogen-activated protein kinase (MAPK) (ERK1/2, p38 and JNK), JAK-STAT, and PI3K-AKT-mTOR pathways-to indirectly modulate EMT, cellular proliferation, and stromal remodeling (Xingmei et al., 2024)