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Suchankova et al

This persistence suggests that the observed histological improvements likely reflect active tissue remodeling rather than merely the passive consequences of decreased fat mass

The REDEFINE 1 trial used a co-administered single-injection product, which is not the same as either of these patterns

Average weight loss runs approximately 14.9% at maximum dose over 68 weeks

The Japanese clinical trial showed peak GLP-1 levels at 8.1 minutes with nasal delivery

I think that we also need longer-term safety data in rheumatology populations in particular, because they haven't been very well studied in these populations