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It was reported that chronic activation of MC4R may lead to persistent high BP despite weight loss, and this BP can be controlled by adrenoceptor blockade

For patients dealing with both fibromyalgia and significant excess weight, that combination is genuinely valuable

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Alternative pharmacological options include phentermine-topiramate (Qsymia) and naltrexone-bupropion (Contrave), though these also carry cardiac considerations

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31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026