Abstract The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane
Cellular Detoxification It aids in the detoxification of harmful substances by forming conjugates with toxins through enzymatic processes (e.g., glutathione S-transferase)
10.5194/aab-64-335-2021 48 LubosE.MahoneyC
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ACTL6A is found to be critical for regulating the glutathione (GSH) metabolism pathway because it upregulates -glutamyl-cysteine ligase catalytic subunit (GCLC) expression, thereby reducing reactive oxygen species (ROS) levels and inhibiting ferroptosis, a regulated form of cell death driven by the accumulation of lipid-based ROS
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