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Clinical Management If glucocorticoid therapy cannot be paused, consider timing sermorelin injections at least 4 hours after the last glucocorticoid dose to take advantage of the circadian nadir of endogenous cortisol

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of medications that are effective treatment for patients with type 2 diabetes mellitus (T2DM) and weight control by stimulating insulin secretion, suppressing glucagon secretion, delaying gastric emptying and decreasing appetite. To investigate whether GLP-1RAs might have a positive impact in patients with knee OA, Zhu and colleagues analyzed data from a prospective, observational, multicenter study called the Shanghai Osteoarthritis Cohort

This appetite regulation is one of the first signs that GLP-1 medications are working

It is important for healthy weight loss and can help boost metabolism

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We pair GLP-1 therapy with muscle-protective peptides so the weight you lose is fat, not lean mass and we design a structured off-ramp so you come off the medication cleanly instead of staying on it forever