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In studies reporting CV benefit associated with weight loss, effects are often attributed to improvements in metabolic abnormalities common in T2D, such as insulin resistance, hyperglycemia, and dyslipidemia [22], as well as reductions in blood pressure, as observed in the Look AHEAD trial [23]

Unlike incretin-based therapies, Cagrilintide primarily works through the amylin signaling pathway to influence appetite and body weight regulation