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Mendelian randomization analysis also showed an inverse relationship between GLP-1 receptor expression and severe DR, indicating the potential of GLP-1RAs in reducing the risk of DR in type 2 diabetes patients (Zheng et al., 2023)

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It binds to GHRH receptors on the anterior pituitary, stimulating endogenous growth hormone release

Whether a patient is prescribed a compounded medication or referred toward a brand-name FDA-approved medication is a clinical decision made by the prescribing clinician based on medical history, the telehealth consultation, and the clinician's professional judgment

Approximately 60% of patients in clinical practice choose chronic treatment specifically to avoid regain

Secondary analyses of these studies suggested that weight loss might be the main driver of GLP-1RA efficacy in MASH, supported by the lack of expression of GLP-1 receptors in the human liver 93