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The complementary mechanisms of these compounds may support a more comprehensive neurological environment than any single peptide alone

doi:10.1007/s11095-013-1007-6 [PMC Full Text] [PubMed] [Crosslink] McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H

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Pain 1987;30:34960.ArticlePubMed 4

Drug elimination occurs through both hepatic metabolism and renal excretion

[36, 37] Unlike conventional hypodermic needles, microneedle systems create transient microchannels that bypass the stratum corneum, enabling efficient transdermal transport of a wide range of molecules, including peptides, proteins, and small drugs, without reaching nerve-rich deeper layers and thus minimizing pain and risk of infection [38, 39]